More articles from Volume 1, Issue 1, 2024
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NOVEL TARGETED VIOLOGEN FOR THE INDUCTION OF SUPEROXIDE PRODUCTION IN MITOCHONDRIA
Medical College of Wisconsin, Milwaukee, United States
Aix Marseille Univ, Marseille, France
Medical College of Wisconsin, Milwaukee, United States
Lodz University of Technology, Łódź, Poland
Aix Marseille Univ, Marseille, France
Editor: Bato Korac
Published: 29.08.2024.
Keynote lectures
Volume 1, Issue 1 (2024)
Abstract
Mitochondrial production of O2•– and H2O2 has been implicated in redox signaling and in the pathogenesis of numerous diseases including cancer, neurodegeneration, and cardiovascular diseases. To understand the exact role of those species, new chemical biology tools for selective and efficient induction of mitochondrial superoxide production are needed. Here, we report the development of a new viologen-based redox cycling agent, mito-diquat (Mito-DQ), capable of inducing targeted mitochondrial O2•– production at significantly higher rates as compared to previously reported mito-paraquat (Mito-PQ), a widely used chemical tool to study mitochondria-dependent redox signaling.
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