More articles from Volume 1, Issue 1, 2024
REDOX AND METABOLIC REPROGRAMMING OF BREAST CANCER CELLS AND ASSOCIATED ADIPOSE TISSUE - THE CORNERSTONES OF ADAPTIVE TUMOUR BEHAVIOUR
INSULIN MODULATES MITOCHONDRIAL STRUCTURAL AND FUNCTIONAL MOSAICISM IN BROWN ADIPOCYTES
NITRITE MITIGATES OXIDATIVE BURST IN ISCHEMIA/REPERFUSION IN BRAIN SLICES
NITRIC OXIDE, SUPEROXIDE AND PEROXYNITRITE – REDOX REGULATION OF THE CARDIOVASCULAR SYSTEM BY NITRO-OXIDATIVE STRESS AND S-NITROS(YL)ATION
DIETARY NITRATE AS PIVOT ON THE GUT MICROBIOTA-HOST REDOX COMMUNICATION
INSULIN MODULATES MITOCHONDRIAL STRUCTURAL AND FUNCTIONAL MOSAICISM IN BROWN ADIPOCYTES
Center for Electron Microscopy, Faculty of Biology, University of Belgrade, Belgrade, Serbia
Center for Electron Microscopy, Faculty of Biology, University of Belgrade, Belgrade, Serbia
Faculty of Biology, Center for Electron Microscopy, University of Belgrade, Belgrade, Serbia
Institute for Biological Research “Sinisa Stankovic”–National Institute of Republic of Serbia, Belgrade, Serbia
Institute for Biological Research “Sinisa Stankovic”–National Institute of Republic of Serbia, Belgrade, Serbia
Center for Electron Microscopy, Faculty of Biology, University of Belgrade, Belgrade, Serbia
Institute for Biological Research “Sinisa Stankovic”–National Institute of Republic of Serbia, Belgrade, Serbia
Center for Electron Microscopy, Faculty of Biology, University of Belgrade, Belgrade, Serbia
Center for Electron Microscopy, Faculty of Biology, University of Belgrade, Belgrade, Serbia
Editor: Bato Korac
Published: 29.08.2024.
Keynote lectures
Volume 1, Issue 1 (2024)
Abstract
Since the discovery of the thermogenic role of brown adipocytes, there was consensus that the biochemical and metabolic function of their mitochondria is uniform. By switching the ATP production between glycolytic pathway and oxidative phosphorylation, brown adipocytes are able to produce heat in mitochondria through uncoupling protein 1 (UCP1). Thermogenically active brown adipocyte mitochondria are characterized by clear morphological features (long, tightly packed cristae). The process of their biogenesis includes an increased number of mitochondria (by division), increase of their surface area, and incorporation of UCP1 as well as specific structural organization of the cristae. But, is it true that all BA mitochondria within one cell are structurally and functionally the same? Do they harbor the same set of enzymes? Actually, the very first cell mosaicism, e.g. Harlequin appearance was shown in brown adipose tissue. This unique uneven UCP1 expression suggests that brown adipocyte’s mitochondria may be heterogeneous regarding production of ATP (bioenergetic) vs. heat (thermogenic) role. This presentation deals with structural and functional mitochondrial mosaicism and changes caused by insulin.
This research was supported by the Science Fund of the Republic of Serbia, #7750238, Exploring new avenues in breast cancer research: Redox and metabolic reprogramming of cancer and associated adipose tissue - REFRAME.
Citation
Copyright
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Article metrics
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
